Note: The TM-U220D is not officially supported on modern macOS for POS applications. Apple has deprecated OPOS. If you must use a Mac, you will need a virtual machine running Windows or middleware like PowerPOS.
For the TM-U220D, Epson provides several driver types depending on the environment: Advanced Printer Driver (APD): epson tm u220d driver exclusive
Here’s a useful guide to understanding and dealing with the situation—a common point of confusion for POS users. Note: The TM-U220D is not officially supported on