Use a third-party MIDI monitor or generic MIDI CC mapping within your DAW. Instead of using Enigma to edit the Radium’s internal memory, simply map the knobs and faders inside your DAW’s "MIDI Learn" function.
The Radium 49 is not "class-compliant," meaning it requires a specific driver to communicate via USB. Official support effectively ended after . m-audio radium 49 driver mac
The last known stable drivers were released for OS X 10.8.5 Mountain Lion, though some users report success using them on 10.9 Mavericks and 10.10 Yosemite. Use a third-party MIDI monitor or generic MIDI
M-Audio Radium 49 is an "end of line" product, meaning official driver support has ceased for recent macOS versions. If you are using a modern Mac (macOS Catalina, Big Sur, Monterey, Ventura, or Sonoma), it will likely not work via a direct USB connection because it is not class-compliant and requires legacy drivers. Apple Discussions Compatibility Status Officially Supported: Up to macOS 10.8.5 (Mountain Lion). Last Known Working (with Drivers): Some users have successfully used the MIDI USB Driver v3.5.3 on macOS Mojave (10.14) or Yosemite (10.10.3). Incompatible: Official support effectively ended after
: Open this utility (found in /Applications/Utilities) to see if the device appears in the MIDI Studio window.