If Windows itself isn't seeing any drive (physical or virtual):
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To prove you have a working file, we provide a verification string. Open Command Prompt as Admin, navigate to your PES 6 folder, and run: pes 6 no cd dvdrom drive found verified
pes6.exe (in the game installation folder, e.g., C:\Program Files\KONAMI\Pro Evolution Soccer 6\ ) If Windows itself isn't seeing any drive (physical
If none of that works, your best bet is to download a (e.g., from FitGirl, R.G. Mechanics, or PES6 community editions) that removes the DVD check entirely. navigate to your PES 6 folder
Try launching the game again.