Resident Evil 4 was never officially released for the PlayStation Portable (PSP). The game originally launched on GameCube and PS2, later appearing on PC, Wii, PS3, PS4, Xbox 360/One, Switch, and mobile platforms (iOS/Android), but not on PSP.

Capcom released a mobile version of Resident Evil 4 (though it lacks the Separate Ways campaign). If you have a smartphone and a Razer Kishi or Backbone controller, you have a better experience than any PSP ISO.

: Be careful when downloading "Resident Evil 4 PSP" files from unknown sites, as they are often malware or clickbait since an official ISO does not exist. Resident Evil 4｜CAPCOM

When die-hard fans search for "Resident Evil 4 PSP ISO," they are often confusing the PSP with its successor, the PS Vita, or conflating RE4 with the two exclusive Resident Evil titles that did come to the PSP:

Open the PPSSPP app and navigate to the directory where you saved the file. Select the game icon to launch. Key Features of Fan-Made Versions

To play these fan-made versions, you typically follow a specific setup process: